KMID : 0043320100330020325
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Archives of Pharmacal Research 2010 Volume.33 No. 2 p.325 ~ p.333
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Antihyperglycemic and Antihyperlipidemic Action of Cinnamomi Cassiae (Cinnamon Bark) Extract in C57BL/Ks db/db Mice
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Choung Se-Young
Kim Sung-Hee
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Abstract
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In previous study, the anti-diabetic effect of Cinnamomi Cassiae extract (Cinnamon bark: Lauraceae) in a type II diabetic animal model (C57BIKsj db/db) has been reported. To explore their mechanism of action, in present study, the effect of cinnamon extract on anti-hyperglycemia and anti-hyperlipidemia was evaluated by measuring the blood glucose levels, serum insulin, and adiponectin levels, serum and hepatic lipids, PPAR¥á mRNA expression in liver and PPAR¥ã mRNA expression in adipose tissue, respectively. Male C57BIKs db/db mice were divided into a diabetic group and cinnamon extract treated group and examined for a period of 12 weeks (200 mg/kg, p.o). The fasting blood glucose and postprandial 2 h blood glucose levels in the cinnamon treated group were significantly lower than those in the control group (p < 0.01), whereas the serum insulin and adiponectin levels were significantly higher in the cinnamon treated group than in the control group (p < 0.05). The serum lipids and hepatic lipids were improved in the cinnamon administered group. Also the PPAR¥á mRNA (liver) and PPAR¥ã mRNA (adipose tissue) expression levels were increased significantly in the cinnamon treated group (p < 0.05). Our results suggest that cinnamon extract significantly increases insulin sensitivity, reduces serum, and hepatic lipids, and improves hyperglycemia and hyperlipidemia possibly by regulating the PPAR-medicated glucose and lipid metabolism.
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KEYWORD
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Cinnamomi Cassia, Anti-hyperglycemia, Anti-hyperlipidemia, Adiponectin, PPAR¥á, PPAR¥ã
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